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Cerebrolysate(solution for injections)
Composition of the preparation
Cerebrolysateis a hydrolysate of cattle brain, it contains free amino acids and peptides. Aminoacid composition ofcerebrolysateis varied in the following limits in milligrams per milliliter (mg/ml): L-lysine – 1,9±0,95; L-histidine – 0,6±0,30; L-arginine – 1,7±0,90; aspartic acid – 1,8±0,80; L-threonine – 1,4±0,70; serine – 2,3±0,95; L-glutamic acid – 5,0±1,25; L-alanine – 3,5±1,75; a L-proline – 1,2±0,50; glycine – 1,4±0,70; L-valine – 2,7±1,35; L-methionine – 1,3±0,65; L-leucine – 4,0±2,00; L-phenylalanine – 1,0±0,50; isoleucine – 2,2±1,40; tyrosine – 0,4±0,25.
Cerebrolysateincreases synthesis of proteins in nervous cells, raises resistance of brain tissue to an intoxication, hypoxia, hypoglycemia, mechanical trauma. The preparation activates integrative processes in the central nervous system, improves concentration of attention, processes of storing and reproducing of the information.
The pharmacokinetic analysis is difficult owing to complex structure of Cerebrolysate, including the sum of free amino acids and peptides.
Cerebrolysate is applied in adult patients with impairment of CNS cortical functions caused by disturbances of a cerebral circulation, at dyscirculatory encephalopathy and in patients with posttraumatic asthenic syndrome.
Dosage and method of administration
The preparation is administrated under doctor prescription.
Cerebrolysateisintroduced intramusculary per 1-5 ml daily or every other day; course of treatment is 20-30 injections.
After 3-6 month interval the course of Cerebrolysatetreatment can be repeated.
Application at pregnancy and lactation:special researches of safety of Cerebrolysateapplication at pregnancy and lactemias were not carried out. There are indications on undesirability of the preparation administration in the Ist trimester of pregnancy.
Injections of a preparation are painful, the irritation of tissues in a place of injection is possible in seldom cases. A rising of arterial pressure can take place at idiopathic hypertensia of II-III severity during Cerebrolysatetreatment.
Relative contraindication to Cerebrolysate administrationis presence of allergic reactions in anamnesis. In these cases the introduction of a preparation is spent under direct observation of a doctor.
Extra care should be kept at application in patients with acute renal failure. The preparation is administrated with care at allergic diathesis, severe convulsive seizures.
Interactions with other medicinal preparations
It was not reported till now on undesirable reactions at combined application of Cerebrolysatewith other medical products.
The phenomena of overdosage at application of the preparation are not described till now.
The form of release
Solution for injections in 1 ml ampoules. 10 ampoules in a box.
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