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What Is MK-677?
Ibutamoren is an unapproved drug that may raise growth hormone and IGF-1.
Ibutamoren (developmental code name MK-677) is an orally-active growth hormone secretagogue and ghrelin receptor agonist being researched as a potential treatment for growth hormone deficiency and sarcopenia [R, R, R, R, R].
A growth hormone secretagogue is simply a substance that signals the pituitary gland in your body to secrete more growth hormone.
MK-677 is orally bioavailable, therefore it can be swallowed (no injections needed) [R].
Much like SARMs, it is non-steroidal, but contrary to popular belief, MK-677 is not a SARM in any capacity, despite commonly being thrown into that category.
Ibutamoren is frequently discussed on online forums for its muscle-building properties. It is available online and used by those wishing to increase their growth hormone levels.
Ibutamoren potentially increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain.
GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition [R].
- Boosts growth hormone
- May increase lean body mass and enhance fat burning
- Strengthens the bones
- May improve sleep quality
- May support cognition and longevity
- Not approved for human use
- May cause swelling and muscle pain
- May increase blood sugar and cause insulin resistance
- Possible undiscovered side effects
Why Some People Use Ibutamoren
Almost all of these points are based on a proposed increase in growth hormone; people assume that ibutamoren increases the effects of growth hormone, as well.
Ibutamoren is frequently used as an anabolic substance, to increase lean body mass – in other words, to create bigger muscles. It is orally active and can be taken once a day.
In a study of eight food-deprived healthy volunteers, ibutamoren reversed protein loss that could cause muscle wasting [R].
Improves Sleep Quality
A small, limited study showed that in both younger and elderly subjects, ibutamoren improved sleep quality and REM (rapid eye movement) sleep duration [R].
Apart from scientific studies, there have been many reports of improved sleep quality across online forums.
Growth Hormone (GH) secretion and muscle mass both decline from mid-puberty throughout life [R].
In a study with 65 older adults, daily ibutamoren increased GH and IGF-1 levels to those of healthy young adults without serious adverse effects [R].
Some people use ibutamoren as a nootropic because it acts on the ghrelin receptor, which has nootropic effects.
Two indirect mechanisms by which ibutamoren may improve brain function include:
- Increasing IGF-1, which improves memory and learning [R, R]
- Boosting REM sleep duration and sleep quality, which is essential for cognitive function [R, R]
Wound Healing and Tissue Regeneration
There are individual reports of ibutamoren being helpful, but scientific studies are lacking.
Suppression of testosterone
MK-677 will not negatively affect natural testosterone levels or endocrine function in any capacity at all, as it does not suppress any male sex hormones.
MK-677 has a much longer shelf-life than reconstituted GH, and does not need to be stored in the fridge or freezer to prevent degradation [R].
Ibutamoren exhibits blatantly anti-catabolic properties, one of which is its ability to retain nitrogen even in a steep caloric deficit.
Improves Immune System
A study on mice showed that a growth hormone secretagogue could generally duplicate the same enhancement of the immune system observed by treating mice with synthetic GH injections.
Statistically significant changes in immunological parameters in the young and old mice treated with the growth hormone secretagogue were noted.
Mechanism Of Action
The likely mechanism of action following MK-677 administration is the activation of the ghrelin receptor by MK-677, with feedback by IGF-I preventing excess GH production [R].
MK-677 does not stimulate a greater quantity of secretion events per day (number of GH pulsations), but rather it stimulates a greater total 24 hour GH production rate [R].
In other words, Ibutamoren can substantially increase the strength of each GH pulsation that occurs in the body.
MK-677 exhibits a dose dependent positive effect on serum GH and IGF-1 levels.
The clinical data suggests that Ibutamoren begins exhibiting diminishing returns above and beyond dosages of 25 mg per day.
The remains consistent among the majority of the clinical studies, with almost every trial utilizing a once daily oral dosage of 25 mg of MK-677 to assess Ibutamoren’s efficacy relative to placebo.
MK-677 Bulking Cycle
In a calorie surplus MK-677 will promote more lean muscle gains than would otherwise be possible to gain naturally.
For use in a performance enhancing context, cycles like the following are commonplace among users.
|PCT (Post-Cycle Therapy)
|10 – 25 mg per day
|10 mg per day
|10 – 25 mg per day
|Nolvadex (40 mg per day) and Clomid (50 mg per day)
|10 – 25 mg per day
|Nolvadex (20 mg per day) and Clomid (25 mg per day)
MK-677 will almost undoubtedly greatly increase appetite.
Besides acting as a potent growth hormone secretagogue, MK-677 is also an oral ghrelin mimetic.
Though not reported in the clinical data that anything that increases your GH and IGF-1 levels will increase your lethargy.
PCT (Post Cycle Therapy)
It does not raise estrogen either, which has an indirect effect on testosterone suppression [R].
As MK-677 doesn’t suppress any sex hormones, or increase any antagonizing hormones, there is no hormonal suppression that occurs via MK-677 use, and therefore would not require a PCT phase.
The elimination half-life of MK-677 is 4.7 hours; with IGF-1 levels remaining elevated with a single oral dose for up to 24 hours [R].
Once per day dosing of MK-677 has proven to be a viable frequency of administration throughout all of the clinical studies to date.
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