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S-4 capsules. This bottle contains 90 capsules of 30mg each. Total 2700mg in the bottle

Andarine is a SARM developed to treat muscle wasting and osteoporosis. It has shown promise in animal studies, where it increased bone density and muscle mass.

The most commonly reported Andarine results among recreational users are significant muscle and strength gains, an increase in muscular detail, dryness and vascularity, as well as an overall improvement in body composition.

Muscle hardness, and lean dry muscle gain are the major appeals of S4 (Andarine) for recreational users.

S4, also known as Andarine (not to be confused with S-40503), is a SARM developed with the aim of treating osteoporosis and muscle wasting.

SARMs (selective androgen receptor modulators) are drugs that bind to the androgen receptor (AR), which is the main site of action of the hormone testosterone.

In the early days, Andarine was described as the ideal SARM due to high oral bioavailability and great muscle- and bone-building effects (studied in animals) [R].

It is orally bioavailable (no injections needed), non-steroidal and has tissue-selective anabolic effects in muscle and bone, while sparing other androgenic effects that come from anabolic androgenic steroids (AAS).

Andarine has a high affinity for the androgen receptor (AR) and therefore mimics the effects of testosterone. However, its effects are much stronger in muscles and bones than in reproductive organs. That is why Andarine and other SARMs are hypothesized to cause fewer side effects than anabolic steroids [R].

Bodybuilders tend to take this unapproved theory as “proof” that they won’t have to deal with severe testosterone suppression and increased estrogens if they take SARMs. However, this is far from true

Start Preparing For Your Best Cycle

Don’t start cycles with the idea that they’ll instantly pass you through all levels of fitness so that you’re suddenly working at maximum potential. These products will only enhance what you’re already doing in the gym. Performance enhancers aren’t really necessary until you’re already pushing your hardest. Then, SARMs can help you achieve the gains that were physiologically impossible before.

To do this, you must have blood tests before each new cycle. From blood tests, you will understand whether you are now ready for a new cycle, or if you should first bring yourself back to normal.

Blood work before the cycle:

• Testosterone (total, free)
• LG, FSH
• SHBG
• ALT, AST
• Estradiol
• Prolactin
• lipid profile (HDL, LDL, Triglycerides)

Here you can find out how each hormone works if you are researching SARMS/Roids/HRT.

Any new cycle will be like a catalyst for you. If you are okay and ready for it, then most likely you will get improvements. If you are not okay and not ready, then chances are you will experience more side effects from SARMs than you could. This may disappoint you in the end.

If, for example, you have initially high estradiol and low testosterone, then when using SARMs (if you are not using the SARMs + SERMs protocol) you can get even more suppression of testosterone and an increase / decrease in estradiol. As a result, you will experience side effects from low testosterone and side effects from high estradiol. If you have low testosterone levels, you can expect difficulty building muscle, burning fat, low libido, erectile dysfunction, brain fog, and a host of other unpleasant effects. You’d better try to fix this before the cycle.

There are several options for increasing your testosterone (clomiphene, hCG, HRT) if you are really low right now without using SARMs.

Go ahead. You have checked your baseline levels of essential hormones, all is well,you have set yourself a cycle goal.

Now we select the SARM.

Here we will check only general information about S4 (Andarine)

S4 (Andarine) was one of the lead candidates in the scope of promising SARMs, being described as the ideal SARM due to once per day dosing, high level of bioavailability, and the significant amount of preclinical data exhibiting a desirable level of anabolic effects in muscle and bone relative to androgenic activity [R].

It is less potent in both anabolic and androgenic effects than other SARMs that were developed like Ostarine and LGD-4033.

S4 acts as a full androgen receptor agonist in muscle tissue and a partial agonist in the prostate [R].

The anabolic activity of S4 is much more selective than Testosterone, and is accomplished with a relatively minor effect on prostate size, and other androgen affected tissues (like hair follicles).

S4’s ability to maintain and increase bone mineral density was evaluated in several preclinical animal models. Each animal study determined that S4 induces anabolic effects in bone, prevents bone loss, and increases overall bone mineral density [R, R, R].

LH (luteinizing hormone) and FSH (follicle stimulating hormone) promote the production of reproductive hormones in men and women, and their suppression could suppress normal estrogen/testosterone levels. Andarine suppressed LH and FSH in castrated rats where these hormones were elevated as a result of castration. However, it had no effect in normal male rats [8, 3].

SARMs have consistently demonstrated suppression of luteinizing hormone (LH) and follicle stimulating hormone (FSH) through the hypothalamus-pituitary-testis axis, thus decreasing testosterone in a dose-dependent manner [R].

S4 is one of the least suppressive SARMs that still retains a promising efficacy profile.

While S4 isn’t as suppressive as some of the more potent SARMs like S23 or LGD-4033, it will still cause endocrine suppression in a dose dependent manner.

All in all, it is unknown if and how much Andarine would suppress testosterone/estrogen production in humans.

The most frequent user-reported side effects are visual issues such as a yellow tint and difficulty adjusting to night vision. These disappear after the drug has been discontinued.

S-4 vs other SARMs?

One thing that is important to note is that all SARMs don’t work the same, despite exerting anabolic activity in the same manner.

Each SARM has a different way it affects the body, as they each have their own anabolic transcription effects, as well as individual specific potency and level of tissue selectivity.

Consequently, results from a SARM like Andarine will likely differ from that of Ostarine or LGD-4033.

Although the mechanism by which Andarine exerts anabolic activity at the androgen receptor is the same as other SARMs, it ultimately leads to different effects on body composition than other SARMs.

How Andarine differs from most other SARMs (aside from S23) in particular results wise is the cosmetic look it gives that no other compound can seem to replicate.

The hard and dry look that Andarine can bring to the muscle is not matched by almost any other SARM.

Andarine isn’t as much of a traditional mass builder, and it is most comparable to something like a moderate dose of Winstrol.

S-4 Dosage

According to users, a common dosing range is 50 to 75 mg per day (divided into 3 doses taken with meals).

There is no established therapeutic dosage of S4

Some start with lower doses of 25 to 50 mg per day. Andarine is often cycled.

S-4  Half-Life

The half-life of S4 is 4 hours in humans [R].

The data assessing the pharmacokinetics of S4 in humans was never officially published, but it is referenced a few times, thus we can assume that there was a trial conducted on humans at some point.

S-4  Side Effects

Vision Impairment

Vision impairment in dark settings is the most notorious S4 side effect.

At high enough dosages (50 mg per day or higher seems to be the standard dosage where this side effect kicks in for most individuals) Andarine can cause a temporary yellow tint to be noticed in sight, and significant issues adjusting from dark to light settings.

This is most notable during the night time.

There are no anecdotal reports of this being permanent, and vision seems to return to normal after discontinuation.

Low libido

Low libido due to lack of androgenicity (if you are on a real SARM, without added androgens). In this case, you may need additional support in the form of libido boosters (Sildenafil, Tadalafil).

Decreased lipids

HDL wasn’t a health marker evaluated in any of the preclinical animal models conducted using S4.However, bioidentical androgens always exhibit a dose dependent suppression of HDL cholesterol, and this is demonstrated in clinical trials conducted using SARMs as well, just to a lesser extent [R, R].

The clinical data shows dose-dependent suppression of HDL cholesterol and triglyceride levels with LGD-4033 usage, as well as all other SARMs that have been evaluated at therapeutic dosages for humans.

Andarine is no different, and will also suppress HDL in a dose dependent manner.This suppression is far less extreme than with traditional anabolic steroids, but it exists nonetheless.

Suppression of testosterone

SARMs have consistently demonstrated suppression of luteinizing hormone (LH) and follicle stimulating hormone (FSH) through the hypothalamus-pituitary-testis axis, thus decreasing testosterone in a dose-dependent manner [R].

S4 is one of the least suppressive SARMs that still retains a promising efficacy profile.

While S4 isn’t as suppressive as some of the more potent SARMs like S23 or LGD-4033, it will still cause endocrine suppression in a dose dependent manner.

One possible side effect of this would be low mood and brain fog. You can check nootropics such as piracetam, Noopept, Bromantane to restore concentration.

Increased Estrogen Or Decreased Estrogen

S4 does not aromatize into Estrogen, but it can still cause a systemic increase or decrease in Estrogen levels.

S4 suppresses natural Testosterone levels, which can result in an unfavorable balance between Testosterone and Estrogen levels in the body.

In addition, S4 has a high binding affinity at the androgen receptor, meaning it is possible that it could divert Testosterone to aromatize that wouldn’t have otherwise, consequently increasing Estrogen levels.

The systemic elevation of Estrogen levels in the body is commonly misinterpreted as the result of prohormone laced SARMs.

High Estrogen Symptoms

• Acne, oily skin
• Erectile dysfunction
• Low libido
• Lethargy
• Gynecomastia (man boobs)
• Irritability
• Depression
• Water retention
• High blood pressure
• Enlarged prostate
• Shrunken testicles
• Sugar cravings

High dosages and/or long-term use of S4 can cause a decrease in systemic Estrogen levels via higher levels of endocrine suppression.

Estrogen facilitated physiological functions in the body are mediated through the aromatization of Testosterone into a sufficient amount of Estrogen.

If S4 usage suppresses endogenous Testosterone levels too low, it can result in Estrogen levels dropping as a consequence of the sheer lack of aromatization occurring in the body in a suppressed state.

When Estrogen levels get too low, an entirely new set of side effects can occur.

Low Estrogen Symptoms

• Dull weak orgasms
• Dry skin and lips
• Dehydration
• Erectile dysfunction
• Low libido
• Irritability
• Mood swings
• Loss of appetite
• Fatigue
• Lethargy

Liver Toxicity

There is no preclinical data on the potential liver toxicity of S4, so it would be prudent to assume that at high enough dosages it could present the same limitations of other SARMs when it comes to taxation on the liver.

SARM + SERM Cycle

This is one of the newest protocols that people are trying out and according to their reports, it is quite effective. The anabolic potential of a SARM cycle is often limited by suppression of endogenous testosterone production

As you may or may not know, SERMs (Selective Estrogen Receptor Modulators) are used after steroid and strong SARM cycles with the goal of kickstarting natural testosterone production and boosting the speed at which it recovers back to baseline. What a lot of users are doing, is taking a SERM during the cycle instead of taking it after the cycle. The logic behind this is that by taking it during the cycle, you can keep your testosterone levels elevated so problems like low libido, erectile dysfunction and lethargy can be avoided. Furthermore, taking a SERM during a cycle would render a PCT useless, since your natural testosterone levels would already be elevated by the end of the cycle.

In addition, the reception SERM during the cycle will make a full PCT is not mandatory, since your natural testosterone levels have to be upgraded by the end of the cycle. You will most likely need a mini PCT to fully restore your hormones to their original values. It is advisable to select dosages based on blood tests.

If you use anti-estrogens on a cycle of SARMs, then it becomes possible to keep luteinizing hormone, follicle-stimulating hormone in the normal values.

SARMs + Clomiphene Protocol

Clomiphene is able to increase LH for a long time without changing the dose. Keeping LH within the normal range will also help keep testosterone within the normal range. Keeping testosterone in the normal range will help convert it into estrogen.

This is how we compensate for the side effects of suppression from SARMs.

Such a cycle can last from four to eight weeks or more. This should be monitored with a blood test. It is necessary that LH, FSH, Testosterone (total, free), Estradiol, Prolactin are within your normal range.

PCT in this case will look like you stop taking SARMs and continue taking Clomiphene for a couple of weeks. If LH and other hormones quickly return to normal, then PCT can be stopped.

A control blood test is best done in the second week of the cycle to adjust the dosage of SARMs and clomiphene. If your SARMs + Clomiphene cycle is long enough, then you must also take a control test once a month.

It is better to take the next control analysis in the second week of PCT. If the results show that your hormones are normal, then PCT can be stopped. If LH, testosterone have not recovered, then PCT can be continued

Weeks	S4 + Clomiphene	PCT (Post-Cycle Therapy)
1-8	S4 25-50 mg per day split into 2-3 dosages. Clomiphene 25mg per 2 days
9-10		Clomiphene 25mg per 2 days

S-4 Cycles

S-4  Bulking Cycle

In a calorie surplus S-4  will promote more lean muscle gains than would otherwise be possible to gain naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users.

Weeks	S-4	PCT (Post-Cycle Therapy)
1-8	S4 25-50 mg per day split into 2-3 dosages
9-10		Nolvadex (20 mg per day) and Clomid (50 mg per day)
11-12		Nolvadex (20 mg per day) and Clomid (25 mg per day)

MK-677 (Ibutamoren) and SARMs like RAD140 or LGD-4033 are commonly stacked alongside S4 in more involving performance enhancement bulking protocols.

For better PCT results, you should adjust your antiestrogen dosage based on blood tests. Read more about it here.

S-4  Cutting Cycle

In a calorie deficit S-4 will retain much more lean muscle mass than would otherwise be possible naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users (the length of this may vary depending on the user’s individual timeline constraints for reaching a goal body fat percentage).

Weeks	S-4	PCT (Post-Cycle Therapy)
1-8	25 – 50 mg per day split into 2-3 dosages
9-10		Nolvadex (20 mg per day) and Clomid (50 mg per day)
11-12		Nolvadex (20 mg per day) and Clomid (25 mg per day)

Cardarine (GW501516) and SARMs like Ostarine (MK-2866) or RAD140 are commonly stacked alongside S4 in more involving performance enhancement cutting protocols.

There are products for the cutting cycle that can significantly increase the results.

Bemitil (Endurance)

Meldonium (Endurance)

Clenbuterol (Endurance + fat loss)

For better PCT results, you should adjust your antiestrogen dosage based on blood tests.

Read more about it here.

S4 PCT (Post Cycle Therapy)

While S4 is one of the least suppressive “mainstream” SARMs, it will still suppress natural Testosterone levels in a dose-dependent manner.

The goal of a PCT phase would be to restore natural Testosterone production as quickly as possible and prevent low androgen or high Estrogen side effects from occurring.

Forgoing PCT will greatly increase the risk of muscle loss, fat gain, among all of the other negative side effects associated with low Testosterone levels.

How much time off should be taken after PCT should not be determined with the bro-science “time on = time off” equation, rather it should be dictated by individual specific factors and blood work.

Blood work on PCT:

• Testosterone (total, free)
• LG, FSH
• SHBG
• Estradiol

Also you can check

• ALT, AST
• Prolactin
• lipid profile (HDL, LDL, Triglycerides)

Related products that can increase the efficiency of the S4  cycle

Other SAPMs for folding in more complex protocols:

MK-677 (Ibutamoren) and SARMs such as S23, LGD-4033 are usually stacked with S4 in more complex performance enhancement protocols.

Libido boosters such as Sildenafil (Viagra), Tadalafil (Cialis), Dapoxetine can help with low libido due to the lack of androgenicity (expected if you are on a true SARM, no test / other androgens).

PCT products such as tamoxifen, toremifene, clomiphene, arimistane, anastrozole, examestan.

Please research the uses of this product before completing your purchase. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received please contact us at sale@brainlabz.ru