S-23 is undoubtedly one of the strongest SARMs in development right now.

It has an extremely high binding affinity, is very suppressive, and is a very potent muscle builder with a high level of tissue selectivity relative to anabolic androgenic steroids.

Some popular bodybuilding blogs claim S-23is a drug that provides the same strength gains and fat loss as steroids without any nasty side effects– but it is not so.

The preclinical data revealed that S-23 is the most suppressive SARM.

Recreational users are quick to label S-23 as a more potent alternative to S4 (Andarine) without the night vision side effect.

S-23 has also shown to decrease prostate size in studies, which is the opposite of a very common negative side effect of anabolic steroids (enlargement of the prostate).

S-23 can be administered orally, as opposed to requiring injections to achieve maximal blood serum concentration levels, which is obviously advantageous when it comes to ease of use and adoption.

Start Preparing For Your Best Cycle

Don’t start cycles with the idea that you’d be able to skip all fitness levels to get to the top and suddenly start working out at maximum potential. These products will only enhance what you’re already doing in the gym. Performance enhancers aren’t really necessary until you’re already pushing your hardest. Then, SARMs can help you achieve the gains that were physiologically impossible before.

For this, make sure you have blood tests done before each new cycle. From blood tests, you will understand whether you are now ready for a new cycle, or if you should first bring yourself back to shape.

Blood work before the cycle should include the following:

• Testosterone (total, free)
• LG, FSH
• SHBG
• ALT, AST
• Estradiol
• Prolactin
• lipid profile (HDL, LDL, Triglycerides)

Here you can find out how each hormone works if you are researching SARMS/Roids/HRT.

Any new cycle will act like a catalyst. If you are in a good shape and ready for it, then most likely you will achieve improvement. If you are not in a good shape and not ready, then chances are you will experience more side effects from SARMs than you could. This may disappoint you in the end.

If, for example, you have initially high estradiol and low testosterone, then when using SARMs (unless you are following the SARMs + SERMs protocol) your testosterone levels will become even more suppressed, accompanied by an increase / decrease in estradiol. As a result, you will experience side effects from low testosterone and side effects from high estradiol. If you have low testosterone levels, you can expect difficulty building muscle, burning fat, low libido, erectile dysfunction, brain fog, and a host of other unpleasant effects. You’d better try to fix this before the cycle.

There are several options for increasing your testosterone (clomiphene, hCG, HRT) if you are really low right now without using SARMs.

Go ahead. You have checked your baseline levels of essential hormones, all is well, you have set yourself a cycle goal.

Now we select the SARM

Here we will check only general information about S-23

S-23 belongs to a new class of drugs called selective androgen receptor modulators (SARM). SARMs mimic testosterone by binding to hormone receptors in specific parts of the body.

Similar to testosterone and other SARMs, researchers hypothesized that S-23 targets the muscle and bone tissues to promote muscle growth and bone health. Some blogs cite animal studies in which S-23 reduced the size of the prostate. However, clinical trials are completely lacking to back up any of these claims [R].

S-23 is becoming increasingly popular in the bodybuilding community. It is allegedly effective at increasing muscle mass and decreasing fat all while having minimal side effects. However, S23 can deplete testosterone levels, which requires users to need post-cycle therapy (PCT) [R].

Research has explored the use of S23 for increasing sexual motivation in women. Other potential uses include preventing muscle loss and increasing bone density [R, R].

Proponents

• Increases lean muscle mass
• Decreases fat mass
• May increase bone strength
• May increase female sexual motivation

Skeptics

• Unapproved drug
• No human studies
• Testosterone depletion
• Testicle shrinkage
• Unknown drug interactions

Sex hormones like testosterone and estrogen are key players for maintaining healthy, strong bones.

SARMs like S-23 may offer unique bone health benefits thanks to their dual action: activating bone-building cells and increasing muscle strength. In animal studies, S-23 increased bone mineral density and muscle mass [R].

The popularity of SARMs is increasing in the bodybuilding community despite a lack of safety research. Without the drawbacks of steroids, SARMs are very appealing appearance enhancers. S-23 is no exception and has a reputation as one of the strongest SARMs on the market.

S-23 is used to achieve a chiseled, hardened look that is sought after in bodybuilding competitions. A popular strategy is to add S23 near the end of the training cycle to achieve a competitive physique.

Some users report stacking S-23 by combining it with other SARMs.

Many reviews praise S23 for its effectiveness. Multiple users compare it to high doses of steroids such as Winstrol (stanozolol) and Anavar (oxandrolone). They say S23 can also prevent muscle loss during calorie deficient cutting cycles.

On the downside, numerous users say S23 can induce “roid-rage” similar to testosterone. According to some, it causes hair loss and darkens the urine.

Users universally agree that PCT (post-cycle therapy) is essential after S-23 because of its testosterone-suppressing effects. To avoid testosterone shutdown, many users take PCT (Clomid or Nolvadex) to restore hormone.

There is no safe or effective S-23 dosage since S23 is an unapproved drug that has not been studied in humans.

Most bodybuilding websites say men take 10 – 30 mg/day divided into 2 doses per day, assuming that S23 has a relatively short half-life of 12 h.

Is S-23 The Strongest SARM?

S23 is being called the strongest SARM available on the market. This is not supported by research

Ostarine and LGD-4033 are also popular high-powered SARMs for bodybuilding. Cell studies show S-23 has a higher binding strength than Ostarine and a similar binding strength to LGD-4033. However, other factors play into their strength and more studies are needed for a reliable comparison [R, R, R].

Users suggest that S-23 is comparable to Ostarine and LGD-4033 when it comes to muscle gain and fat loss. Reports of side effects are similar, although S23 appears to trigger more testosterone shutdown. According to reviews, what sets S23 apart is the way it hardens the body to produce greater muscle detail.

S23 has a higher binding affinity than RAD140, is more suppressive, but will also build more muscle and strength.

With that being said, S23 is more androgenic than RAD140 and will result in more androgenic side effects.

Anecdotally RAD140 is much more androgenic than it appeared to be in its preclinical profile, however, S23 still exceeds it in terms of overall androgenicity.

S23 will also dry out the muscle more than RAD140.

Whether this is via dehydration or a direct conditioning effect this remains unknown, but pound for pound it is safe to say that S23 is a more potent anabolic and androgenic agent in general than RAD140.

S23 is purported by many to be a jacked up version of S4 without the night vision side effect.

It is true that S23 does not cause the same vision side effect as S4 and is a more potent muscle builder.

S-23 Dosage

Dosages of 10 – 30 mg per day are commonly used in a recreational context for muscle building purposes.
There is no established therapeutic dosage of S23

S-23  Half-Life

The mean terminal half-life of S23 in rats is 11.9 hours [R].

The half-life of S23 in humans is unknown, and would require mathematical estimation, or a clinical study (ideally) to determine it.

S-23  Side Effects

Aggression

S23 users commonly report very blatant increases in aggression, similar to that of RAD140 and highly androgenic anabolic steroids.

Low libido

Low libido due to lack of androgenicity (if you are on a real SARM, without added androgens). In this case, you may need additional support in the form of libido boosters (Sildenafil, Tadalafil).

Decreased lipids

Expectedly, S23 induces a dose dependent lowering of HDL cholesterol and triglyceride levels. Any anabolic androgenic compound will suppress HDL cholesterol in a dose dependent manner. This has been consistently shown in other clinical trials conducted on other SARMs as well [R, R].

Suppression of testosterone

S-23 is still more tissue selective than non-selective androgens like Testosterone, it has shown to be a full agonist in androgenic and anabolic tissues [R].

Just like anabolic steroids, SARMs have all consistently exhibited suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) through the Hypothalamus-Pituitary-Testes-Axis.The result of this is decreasing natural testosterone production in a dose-dependent manner [R].

One possible side effect of this would be low mood and brain fog. You can check nootropics such as piracetam, Noopept, Bromantane to restore concentration.

Increased Estrogen Or Decreased Estrogen

S-23 does not aromatize into Estrogen, but it still has a large impact on the ratio of Testosterone:Estrogen in the body.

Liver Toxicity

There is no preclinical data on the potential liver toxicity of S23, so it would be prudent to assume that at high enough dosages it could present the same limitations of other SARMs when it comes to taxation on the liver.

SARM + SERM Cycle

This is one of the newest protocols that people are trying out and according to their reports, it is quite effective. The anabolic potential of a SARM cycle is often limited by suppression of endogenous testosterone production

As you may or may not know, SERMs (Selective Estrogen Receptor Modulators) are used after steroid and strong SARM cycles with the goal of kickstarting natural testosterone production and boosting the speed at which it recovers back to baseline. What a lot of users are doing, is taking a SERM during the cycle instead of taking it after the cycle. The logic behind this is that by taking it during the cycle, you can keep your testosterone levels elevated so problems like low libido, erectile dysfunction and lethargy can be avoided. Furthermore, taking a SERM during a cycle would render a PCT useless, since your natural testosterone levels would already be elevated by the end of the cycle.

In addition, the reception SERM during the cycle will make a full PCT is not mandatory, since your natural testosterone levels have to be upgraded by the end of the cycle. You will most likely need a mini PCT to fully restore your hormones to their original values. It is advisable to select dosages based on blood tests.

If you use anti-estrogens on a cycle of SARMs, then it becomes possible to keep luteinizing hormone, follicle-stimulating hormone in the normal values.

SARMs + Clomiphene Protocol

Clomiphene can increase LH for a long time without changing the dose. Keeping LH within the normal range will also help keep testosterone within the normal range. Keeping testosterone in the normal range will help convert it into estrogen.

This is how we compensate for the side effects of suppression from SARMs.

Such a cycle can last from four to eight weeks or more. This should be monitored with a blood test. Make sure that LH, FSH, Testosterone (total, free), Estradiol, Prolactin are within your normal range.

PCT in this case will be similar to stopping taking SARMs and continuing taking Clomiphene for a couple of weeks. If LH and other hormones quickly return to normal, then PCT can be stopped.

A control blood test is best done in the second week of the cycle to adjust the dosage of SARMs and clomiphene. If your SARMs + Clomiphene cycle is long enough, then you must also take a control test once a month.

It is better to take the next control analysis in the second week of PCT. If the results show that your hormones are normal, then PCT can be stopped. If LH, testosterone have not recovered, then PCT can be continued.

Weeks	S23 + Clomiphene	PCT (Post-Cycle Therapy)
1-8	S23 10-30 mg per day split into 2 dosages. Clomiphene 25mg per 2 days
9-10		Clomiphene 25mg per 2 days

 

S-23 Cycles

S-23  Bulking Cycle

In a calorie surplus S-23  will promote more lean muscle gains than would otherwise be possible to gain naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users.

Weeks	S-23	PCT (Post-Cycle Therapy)
1-8	S-23 10-30 mg per day split into 2 dosages
9-10		Nolvadex (20 mg per day) and Clomid (50 mg per day)
11-12		Nolvadex (20 mg per day) and Clomid (25 mg per day)

MK-677 (Ibutamoren) and SARMs like RAD140 or LGD-4033 are commonly stacked alongside S23 in more involving performance enhancement bulking protocols.

For better PCT results, you should adjust your antiestrogen dosage based on blood tests.

S-23  Cutting Cycle

In a calorie deficit S-23  will retain much more lean muscle mass than would otherwise be possible naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users (the length of this may vary depending on the user’s individual timeline constraints for reaching a goal body fat percentage).

Weeks	S-23	PCT (Post-Cycle Therapy)
1-8	10 – 30 mg per day split into 2 dosages
9-10		Nolvadex (20 mg per day) and Clomid (50 mg per day)
11-12		Nolvadex (20 mg per day) and Clomid (25 mg per day)

Cardarine (GW501516) and SARMs like Ostarine (MK-2866) or S4 (Andarine) are commonly stacked alongside S-23 in more complex cutting protocols to enhance performance.

There are products for the cutting cycle that can significantly increase the results.

Bemitil (Endurance)

Meldonium (Endurance)

Clenbuterol (Endurance + fat loss)

For better PCT results, you should adjust your antiestrogen dosage based on blood tests.

S23 PCT (Post Cycle Therapy)

S23 is very suppressive and undoubtedly requires a PCT phase (post-cycle therapy) for efficient recovery. If you do blood tests on PCT (2^nd week), you can adjust your antiestrogen dosage correctly.

The goal of a PCT phase would be to restore natural Testosterone production as quickly as possible and prevent low androgen or high Estrogen side effects from occurring.

Forgoing PCT will greatly increase the risk of muscle loss, fat gain, among all of the other negative side effects associated with low Testosterone levels.

How much time off should be taken after PCT should not be determined with the bro-science “time on = time off” equation, rather it should be dictated by individual specific factors and blood work.

Blood work on PCT:

• Testosterone (total, free)
• LG, FSH
• SHBG
• Estradiol

Also you can check

• ALT, AST
• Prolactin
• lipid profile (HDL, LDL, Triglycerides)

Related products that can increase the efficiency of the S23  cycle

Other SAPMs for folding in more complex protocols:

MK-677 (Ibutamoren) and SARMs such as LGD-4033 are usually stacked with S23 in more complex performance enhancement protocols.

Libido boosters such as Sildenafil (Viagra), Tadalafil (Cialis), Dapoxetine can help with low libido due to the lack of androgenicity (expected if you are on a true SARM, no test / other androgens).

PCT products such as tamoxifen, toremifene, clomiphene, arimistane, anastrozole, examestan.

Please research the uses of this product before completing your purchase. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received please contact us at sale@brainlabz.ru